Toshiyuki Sakaki Selected Research

Alopecia (Baldness)

10/2023	Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector.
1/2017	Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.

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Toshiyuki Sakaki Research Topics

Disease

13	Neoplasms (Cancer) 04/2022 - 10/2003
12	Osteoporosis 01/2023 - 06/2005
11	Rickets (Rachitis) 11/2023 - 05/2004
5	Prostatic Neoplasms (Prostate Cancer) 12/2021 - 09/2007
5	Leukemia 01/2019 - 10/2003
5	Osteosarcoma (Osteogenic Sarcoma) 01/2018 - 04/2004
4	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019 - 10/2003
2	Alopecia (Baldness) 10/2023 - 01/2017
2	Chronic Renal Insufficiency 04/2022 - 01/2019
2	Rheumatoid Arthritis 01/2019 - 05/2011
2	Hypocalcemia 01/2018 - 01/2017
2	Breast Neoplasms (Breast Cancer) 10/2015 - 05/2009
2	Hypercalcemia (Milk Alkali Syndrome) 04/2013 - 10/2012
2	Colonic Neoplasms (Colon Cancer) 05/2004 - 04/2004
2	Hepatoblastoma 05/2004 - 04/2004
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2023
1	Developmental Bone Diseases (Bone Dysplasia) 10/2023
1	Weight Loss (Weight Reduction) 01/2021
1	Body Weight (Weight, Body) 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 01/2020
1	Multiple Sclerosis 01/2019
1	Cognitive Dysfunction 01/2018
1	Hypertrophy 01/2018
1	Bone Resorption 01/2018
1	Postmenopausal Osteoporosis 01/2018
1	Immune System Diseases (Immune Disorders) 01/2018
1	Hyperglycemia 01/2017
1	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2017
1	Type 2 Diabetes Mellitus (MODY) 01/2017
1	Mobility Limitation (Difficulty Walking) 01/2017
1	Hypophosphatemic Rickets 01/2017
1	Hypoglycemia (Reactive Hypoglycemia) 01/2017
1	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 10/2015
1	Smith-Lemli-Opitz Syndrome 03/2014
1	Nephrocalcinosis 04/2013
1	Undiagnosed Diseases 04/2013
1	Nephrolithiasis 04/2013
1	Hypercalciuria 04/2013
1	Liver Neoplasms (Liver Cancer) 10/2012
1	Muscular Diseases (Myopathy) 10/2010
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 08/2009

Drug/Important Bio-Agent (IBA)

20	Vitamin D FDA LinkGeneric 11/2023 - 05/2004
19	hydroxide ionIBA 01/2023 - 04/2004
10	Calcitriol Receptors (Calcitriol Receptor)IBA 11/2023 - 05/2009
8	Vitamin D3 24-HydroxylaseIBA 04/2022 - 05/2009
8	LigandsIBA 12/2021 - 01/2006
6	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)IBA 01/2018 - 05/2004
5	Cholecalciferol (Vitamin D3)FDA Link 11/2016 - 01/2005
4	Therapeutic UsesIBA 10/2023 - 11/2016
4	OsteocalcinIBA 01/2018 - 09/2009
3	CalciumIBA 10/2023 - 06/2005
3	EnzymesIBA 04/2022 - 01/2012
3	AndrogensIBA 12/2021 - 09/2009
3	Calcitriol (Calcijex)FDA LinkGeneric 01/2020 - 05/2009
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2012 - 06/2005
3	Calcifediol (Calcidiol)FDA Link 08/2005 - 05/2004
2	paricalcitol (Zemplar)FDA Link 01/2019 - 09/2009
2	Parathyroid Hormone (Parathormone)IBA 01/2018 - 04/2013
2	eldecalcitol (ED 71)IBA 01/2018 - 03/2015
2	LuciferasesIBA 10/2015 - 09/2009
2	Vitamin D-Binding ProteinIBA 01/2013 - 09/2009
2	19- nor- 2- (3- hydroxypropyl)- 1,25- dihydroxyvitamin D3IBA 11/2011 - 09/2009
2	1,25-dihydroxyvitamin DIBA 01/2006 - 10/2003
1	Cytochrome P450 Family 24IBA 04/2022
1	VitaminsIBA 04/2022
1	Nucleotide AptamersIBA 04/2022
1	Androgen Receptors (Androgen Receptor)IBA 12/2021
1	1,25-dihydroxyergocalciferolIBA 01/2020
1	iguratimodIBA 01/2019
1	Dimethyl FumarateIBA 01/2019
1	Antirheumatic Agents (DMARD)IBA 01/2019
1	1,3- dihydroxy- 4,4,5,5- tetramethyl- 2- (4- carboxyphenyl)tetrahydroimidazole (NOR 1)IBA 01/2019
1	MineralsIBA 01/2018
1	alfacalcidolIBA 01/2018
1	GTP-Binding Proteins (G-Protein)IBA 01/2017
1	EquolIBA 01/2017
1	daidzeinIBA 01/2017
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2017
1	Streptozocin (Streptozotocin)FDA Link 01/2017
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Insulin (Novolin)FDA Link 01/2017
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 01/2017
1	SterolsIBA 03/2015
1	Oxidoreductases (Dehydrogenase)IBA 03/2015
1	7-dehydrocholesterolIBA 03/2014
1	Mixed Function Oxygenases (Monooxygenases)IBA 04/2013
1	calcium phosphateIBA 04/2013
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 11/2011
1	CarbonIBA 11/2011
1	propionic acid (potassium propionate)IBA 05/2011
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 05/2011
1	Fluvastatin FDA Link 10/2010
1	XenobioticsIBA 08/2009
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 08/2009
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 08/2009
1	indoleIBA 08/2009
1	beta CateninIBA 08/2009

Therapy/Procedure

5	Therapeutics 01/2014 - 09/2007
1	Injections 10/2023
1	Chemoprevention 08/2009